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Genetics in NDIT

A total of 943 NDIT participants were genotyped in 2017 using the Illumina Global Screening Array on previously collected blood and saliva samples. This permits genetic association studies with a wide range of diverse phenotypes (e.g., nicotine dependence, blood pressure, body weight, depressive symptoms) using candidate gene approaches or methods based on genetic risk scores.

Funding

2020-21     Genetic impact on youth vaping: Extending known genetic risk factors in smoking and tobacco-related

                   illnesses to vaping

                   CIHR Catalyst Grant: Health Effects of Vaping - $99,942

                   Co-Principal Investigators: Chenoweth MJ, Tyndale RF

                   Co-Investigators: Eisenberg M; Hammond D, O'Loughlin J, Porath A, Sylvestre MP

 

2016-20    Genetic determinants of individual blood pressure trajectories in adolescents.

                  CIHR - $355,492

                  Co-Principal Investigators: Sylvestre MP; O’Loughlin J

                  Co-Investigators: Engert J, Karp I, Williams S  

2017-18    Depressive symptoms in adolescence: The independent and interactive influences of genetics and physical activity over time.

                 CIHR Operating Grant: Analyses of existing Canadian cohorts and databases related to reproductive, child and maternal health

                 and Cancer Control program - $75,000

                 Co-Principal Investigators: Brunet J, Sylvestre MP

                 Co-Investigators: Karp I, Engert J, Williams S, O’Loughlin J

Publications

  1. Chagnon M, O’Loughlin J, Engert JC, Karp I, Sylvestre MP. Missing single nucleotide polymorphisms in Genetic Risk Scores: A simulation study. Plos One. 2018 Jul 19;13(7):e0200630. doi: 10.1371/journal.pone.0200630. PMID: 30024900; PMCID: PMC6053141.

  2. Chenoweth MJ, Sylvestre MP, Contreras G*, Novalen M, O’Loughlin J, Tyndale RF. Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers. Drug Alcohol Depend. 2016 Jan 1;158:139-46. doi: 10.1016/j.drugalcdep.2015.11.017. Epub 2015 Nov 21. PMID: 26644138; PMC4698159.

  3. O’Loughlin J, Sylvestre MP, Labbe A, Low N, Roy-Gagnon MH, Dugas EN, Karp I, Engert JC. Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. PLoS One 2014 Dec 29:9(12):e115716. doi: 10.1371/journal.pone.0115716. PMID: 25545355; PMCID: PMC4278712.

  4. Pedneault M, Labbe A, Roy-Gagnon MH, Low NC, Dugas E, Engert JC, O'Loughlin J. The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. Addict Behav 2014;39:316-20. doi: 10.1016/j.addbeh.2013.08.033. Epub 2013 Sep 7. PMID: 24119711.

  5. Chenoweth MJ, O’Loughlin J, Sylvestre MP, Tyndale RF. CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers. Pharmacogenet Genomics 2013;23(4):232-5.

  6. Malard L, Kakinami L, O'Loughlin J, Roy-Gagnon MH, Labbe A, Pilote L, Hamet P, Tremblay J, Paradis G. The association between the Angiotensin-Converting Enzyme-2 (ACE2) gene and blood pressure in a cohort of Canadian adolescents. BMC Med Genet 2013;14:117.

  7. O’Loughlin J, Paradis G, Kim W, DiFranza J, Meshefedjian G, McMillan-Davey E, Wong S, Hanley J, Tyndale RF. Genetically decreased CYP2A6 and the risk of onset of tobacco dependence: a prospective study of novice smokers. Tob Control 2004;13:422-8.

  8. Koudsi NA, O’Loughlin J, Rodriguez D, Audrain-McGovern J, Tyndale RF. The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence. J Pediatr Biochem 2010;1:105-23 (Invited Article). Available at: https://content.iospress.com/articles/journal-of-pediatric-biochemistry/jpb00014