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Genetics in NDIT Publications

  1. Alsaafin A, Chenoweth MJ, Sylvestre MP, O'Loughlin J, Tyndall RF. Genetic variation in fatty acid amide hydrolase (FAAH): Associations with early drinking and smoking behaviors​. Addict Behav. Feb 2023; 137(107545). 

  2. Alsaafin A, Chenoweth MJ, Sylvestre MP, O'Loughlin J, Tyndale RF. Does genetic variation in a bitter taste receptor gene alter early smoking behaviors in adolescents and young adults? Addiction. 2022 Mar 16. doi: 10.1111/add.15871. Epub ahead of print. PMID: 35293057.

  3. Mbutiwi F, Dessy T, Sylvestre M-P. Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity. Front Genet. 2022;13.

  4. Goulet D, O’Loughlin J, Sylvestre MP.  Association of genetic variants with body-mass index and blood pressure in adolescents: A replication study. Frontiers in Genetics, 2021;

  5. Chagnon M, O’Loughlin J, Engert JC, Karp I, Sylvestre MP. Missing single nucleotide polymorphisms in Genetic Risk Scores: A simulation study. Plos One. 2018 Jul 19;13(7):e0200630. doi: 10.1371/journal.pone.0200630. PMID: 30024900; PMCID: PMC6053141.

  6. Chenoweth MJ, Sylvestre MP, Contreras G, Novalen M, O’Loughlin J, Tyndale RF. Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers. Drug Alcohol Depend. 2016 Jan 1;158:139-46. doi: 10.1016/j.drugalcdep.2015.11.017. Epub 2015 Nov 21. PMID: 26644138; PMC4698159.

  7. O’Loughlin J, Sylvestre MP, Labbe A, Low N, Roy-Gagnon MH, Dugas EN, Karp I, Engert JC. Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. PLoS One 2014 Dec 29:9(12):e115716. doi: 10.1371/journal.pone.0115716. PMID: 25545355; PMCID: PMC4278712.

  8. Pedneault M, Labbe A, Roy-Gagnon MH, Low NC, Dugas E, Engert JC, O'Loughlin J. The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke. Addict Behav 2014;39:316-20. doi: 10.1016/j.addbeh.2013.08.033. Epub 2013 Sep 7. PMID: 24119711.

  9. Chenoweth MJ, O’Loughlin J, Sylvestre MP, Tyndale RF. CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers. Pharmacogenet Genomics 2013;23(4):232-5.

  10. Malard L, Kakinami L, O'Loughlin J, Roy-Gagnon MH, Labbe A, Pilote L, Hamet P, Tremblay J, Paradis G. The association between the Angiotensin-Converting Enzyme-2 (ACE2) gene and blood pressure in a cohort of Canadian adolescents. BMC Med Genet 2013;14:117.

  11. O’Loughlin J, Paradis G, Kim W, DiFranza J, Meshefedjian G, McMillan-Davey E, Wong S, Hanley J, Tyndale RF. Genetically decreased CYP2A6 and the risk of onset of tobacco dependence: a prospective study of novice smokers. Tob Control 2004;13:422-8.

  12. Koudsi NA, O’Loughlin J, Rodriguez D, Audrain-McGovern J, Tyndale RF. The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence. J Pediatr Biochem 2010;1:105-23 (Invited Article). Available at:

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